マイナーな膵臓acinar cell解析。手法は古典的だけれど、しっかり忠実に。ただ幾つか引っかかる。peer review記録見るとやはり指摘されてるが答えていないor強気なはぐらかし。うーん🤔 Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis | Nature https://t.co/My9x2vRv94
Pancreatic adenocarcinoma (PDAC) is one of the leading causes of cancer death worldwide. Human tissue studies and model-based studies show that early mutations are found in many stem cell diseases that promote tumor development.#FDSC808 https://t.co/PLxn
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @jyasuda1: TERT遺伝子座をトレースすることで、膵癌の発生機構を探った論文。腺房細胞の中にまれTERT発現+になる細胞が出現、膵臓の外分泌部に広く分布する。恒常性維持の過程でTERT陽性細胞がクローン性増殖を示し、ここにKRAS変異が入ると更に増殖が高まるよう…
TERT遺伝子座をトレースすることで、膵癌の発生機構を探った論文。腺房細胞の中にまれTERT発現+になる細胞が出現、膵臓の外分泌部に広く分布する。恒常性維持の過程でTERT陽性細胞がクローン性増殖を示し、ここにKRAS変異が入ると更に増殖が高まるようだ。https://t.co/oHak3lYFr3
RT @NatRevClinOncol: during pancreatic homeostasis, TERThigh acinar cells renew pancreas by forming expanding clones of acinar cells; Kras…
during pancreatic homeostasis, TERThigh acinar cells renew pancreas by forming expanding clones of acinar cells; Kras mut in TERThigh acinar cells accelerates acinar clone formation and might represent early cancer precursor lesion https://t.co/jliOoqFgTc
RT @stemcellpodcast: On our latest episode, we talk about the origins of #PancreaticCancer. Dr. Steven Artandi's (@SCIDirector) lab at @St…
RT @stemcellpodcast: On our latest episode, we talk about the origins of #PancreaticCancer. Dr. Steven Artandi's (@SCIDirector) lab at @St…
RT @stemcellpodcast: On our latest episode, we talk about the origins of #PancreaticCancer. Dr. Steven Artandi's (@SCIDirector) lab at @St…
On our latest episode, we talk about the origins of #PancreaticCancer. Dr. Steven Artandi's (@SCIDirector) lab at @StanfordCancer used #LineageTracing to find a link between renewal mechanisms in the pancreas and the initiation of pancreatic cancer. 🔗 ht
RT @NatResCancer: 📫#CancerNaturePortfolio research @nature: Acinar cell clonal expansion in pancreas homeostasis and #carcinogenesis, by P…
RT @kemkem_pharm: 明日はこれ読んでみます😌 https://t.co/4aehUOOZlx テロメラーゼ逆転写酵素を高発現しているレアな膵腺房細胞の集団とすい臓がん
RT @SCIDirector: Congrats to star postdoc Patrick Neuhofer on his work in @Nature linking renewal mechanisms in pancreas to pancreas cancer…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
A must read! Congratulations to Patrick for this fascinating work https://t.co/DBLBNxLhZk
📫#CancerNaturePortfolio research @nature: Acinar cell clonal expansion in pancreas homeostasis and #carcinogenesis, by P Neuhöfer et al., S Artandi @SCIDirector @StanfordCancer. https://t.co/I5i7BhrBvt #cancerorigins #PDAC 🦀Check all new content: https:
★TERT+はすい臓内に点在し,一年間追跡してみると自己分裂が盛ん(コロニー化) ★TERT+にKRAS変異G12Dを加えたり炎症を引き起こすと,TERT+からPanINやmetaplasiaなどの腫瘍病変が生まれる がん化したTERT+を選択的にモニターしたり治療したりする必要がありそうだ https://t.co/4aehUOOZlx
明日はこれ読んでみます😌 https://t.co/4aehUOOZlx テロメラーゼ逆転写酵素を高発現しているレアな膵腺房細胞の集団とすい臓がん
Beautiful work linking key features for cancer development "Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis" https://t.co/JYyVh1mzPC
'Neuhöfer et al. found that the Kras mutation accelerates the growth of clones of acinar cells expressing Tert, compared with the growth of acinar cells that were randomly labelled irrespective of their Tert-expression status.' https://t.co/00bCvOFeeO
RT @Aiims1742: What role might the telomerase reverse transcriptase (TERT) high acinar cell subpopulation play in #PancreaticCancer pathoge…
RT @PitarresiLab: Exciting paper out today in @Nature by @SCIDirector using new mouse models to show that TERT+ acinar cell subpopulations…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
Dr. Steven Artandi (@SCIDirector) and colleagues at @StanfordMed identify a rare TERT-positive subpopulation of #pancreatic acinar cells dispersed throughout the exocrine compartment which also represents an early cancer precursor lesion. 🙌 https://t.co/
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @PitarresiLab: Exciting paper out today in @Nature by @SCIDirector using new mouse models to show that TERT+ acinar cell subpopulations…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @PitarresiLab: Exciting paper out today in @Nature by @SCIDirector using new mouse models to show that TERT+ acinar cell subpopulations…
RT @PitarresiLab: Exciting paper out today in @Nature by @SCIDirector using new mouse models to show that TERT+ acinar cell subpopulations…
Absolutely exciting
Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis https://t.co/13F1hbD7c1
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @lauradelongwood: Full paper: https://t.co/uMFZDW3jEP
Exciting story on TERT+ early pancreatic cancer precursor lesions: https://t.co/ahirDCqcsK
RT @Aiims1742: What role might the telomerase reverse transcriptase (TERT) high acinar cell subpopulation play in #PancreaticCancer pathoge…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Congrats to star postdoc Patrick Neuhofer on his work in @Nature linking renewal mechanisms in pancreas to pancreas cancer…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Congrats to star postdoc Patrick Neuhofer on his work in @Nature linking renewal mechanisms in pancreas to pancreas cancer…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
Congratulations on this beautiful work!
Very interesting. The debate about pancreatic “stem” cells is still on 🔥 and this paper is a valuable piece of information.
Exciting paper out today in @Nature by @SCIDirector using new mouse models to show that TERT+ acinar cell subpopulations can initiate pancreatic cancer! https://t.co/obO2OxkQiR
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
Congrats to @SCIDirector and team! I have been excitedly waiting to read this one! #CancerResearch
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
@lauradelongwood @Aiims1742 @NatureNV Thank you @lauradelongwood and @Aiims1742 for your exciting News and Views in @Nature featuring our paper today!! https://t.co/x2TgGL5fkq
Congrats to star postdoc Patrick Neuhofer on his work in @Nature linking renewal mechanisms in pancreas to pancreas cancer. He found that acinar cells in human tissue sustain Kras mutations providing evidence for a very early step in pancreas cancer. https
RT @SCIDirector: Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme express…
Our paper is out in @Nature today: we investigated the role that telomerase reverse transcriptase (Tert)—an enzyme expressed in a particular subset of acinar cells—plays in pancreatic tumorigenesis. #pancreaticcancer #pdac @cmroake @Greg_Charville https:/
RT @DanielJDrucker: Friendly and aberrant expansion of the acinar cell compartment of the pancreas @nature https://t.co/u126bSEBqF
RT @Aiims1742: What role might the telomerase reverse transcriptase (TERT) high acinar cell subpopulation play in #PancreaticCancer pathoge…
Friendly and aberrant expansion of the acinar cell compartment of the pancreas @nature https://t.co/u126bSEBqF
Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis https://t.co/1GRwBaQSkw https://t.co/11fall6q9I | #research #manuscripts @nature
RT @Aiims1742: What role might the telomerase reverse transcriptase (TERT) high acinar cell subpopulation play in #PancreaticCancer pathoge…
What role might the telomerase reverse transcriptase (TERT) high acinar cell subpopulation play in #PancreaticCancer pathogenesis? Paper in @Nature this morning by @SCIDirector & colleagues. See accompanying @NatureNV by @lauradelongwood (mainly) &
Full paper: https://t.co/uMFZDW3jEP