| Title |
Risk factors for intensive care unit admission in patients with severe leptospirosis: a comparative study according to patients’ severity
|
|---|---|
| Published in |
BMC Infectious Diseases, February 2016
|
| DOI | 10.1186/s12879-016-1349-x |
| Pubmed ID | |
| Authors |
Elizabeth De Francesco Daher, Douglas Sousa Soares, Anna Tereza Bezerra de Menezes Fernandes, Marília Maria Vasconcelos Girão, Pedro Randal Sidrim, Eanes Delgado Barros Pereira, Natalia Albuquerque Rocha, Geraldo Bezerra da Silva |
| Abstract |
The aim of this study is to investigate predictive factors for intensive care unit (ICU) admission among patients with severe leptospirosis. This is a retrospective study with all patients with severe leptospirosis admitted to a tertiary hospital. Patients were divided in ICU and ward groups. Demographical, clinical and laboratory data of the groups were compared as well as acute kidney injury (AKI) severity, according to the RIFLE criteria (R = Risk, I = Injury, F = Failure, L = Loss, E = End-stage kidney disease). A total of 206 patients were included, 83 admitted to ICU and 123 to ward. Mean age was 36 ± 15.8 years, with 85.9 % males. Patients in ICU group were older (38.8 ± 15.7 vs. 34.16 ± 15.9 years, p = 0.037), had a shorter hospital stay (4.13 ± 3.1 vs. 9.5 ± 5.2 days, p = 0.0001), lower levels of hematocrit (29.6 ± 6.4 vs. 33.1 ± 8.6 %, p = 0.003), hemoglobin (10.2 ± 2.4 vs. 11.6 ± 1.9 g/dL, p < 0.0001), and platelets (94,427 ± 86,743 vs. 128,896 ± 137,017/mm(3), p = 0.035), as well as higher levels of bilirubin (15.0 ± 12.2 vs. 8.6 ± 9.5 mg/dL, p = 0.001). ICU group also had a higher frequency of severe AKI (RIFLE-"Failure": 73.2 % vs. 54.2 %, p < 0.0001) and a higher prevalence of dialysis requirement (57.3 % vs. 27.6 %, p < 0.0001). Mortality was higher among ICU patients (23.5 % vs. 5.7 %, p < 0.0001). Independent predictors for ICU admission were tachypnea (p = 0.027, OR = 13, CI = 1.3-132), hypotension (p = 0.009, OR = 5.27, CI = 1.5-18) and AKI (p = 0.029, OR = 14, CI = 1.3-150). Ceftriaxone use was a protective factor (p = 0.001, OR = 0.13, CI = 0.04-0.4). Independent risk factors for ICU admission in leptospirosis include tachypnea, hypotension and AKI. Ceftriaxone was a protective factor for ICU admission, suggesting that its use may prevent severe forms of the disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 109 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 18 | 16% |
| Student > Bachelor | 18 | 16% |
| Student > Master | 12 | 11% |
| Researcher | 11 | 10% |
| Student > Doctoral Student | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 31 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 37% |
| Veterinary Science and Veterinary Medicine | 9 | 8% |
| Nursing and Health Professions | 7 | 6% |
| Immunology and Microbiology | 4 | 4% |
| Engineering | 4 | 4% |
| Other | 12 | 11% |
| Unknown | 33 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2016.
All research outputs
#17,812,737
of 22,883,326 outputs
Outputs from BMC Infectious Diseases
#5,126
of 7,690 outputs
Outputs of similar age
#270,839
of 397,460 outputs
Outputs of similar age from BMC Infectious Diseases
#74
of 101 outputs
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