@IShowH8 I am aware of this old paper. The problem with it was unrealistic assumptions. It has been disproven by more recent large seq data that do not rely on any assumptions. Just count # of PTV per race (protein truncating variants), Africans most. htt
See Figure 5B. Just counting variants numbers and no assumptions of any sort https://t.co/2hFS2Es2xI
@RossiTimo @Eero49307589 En toki. Kyllä sen teki ammattilaiset. https://t.co/R6QKChBLpe
@Rounwytha333 lol, sure man. I did respond to you, the problem was your argument was nonsense https://t.co/unqRomXihv
@TaaviHorila @heliramax Tutkijat ovat kanssasi eri mieltä. - https://t.co/m9aS5Z6khQ - https://t.co/qtZWd6CajU
@Rounwytha333 "No genetic study does this" Wrong. https://t.co/I1hHHeJuZ4 Stop imagining up fake things geneticists laugh in the face of https://t.co/G6xJmCivpH
@TheEdgeIsrael Here's a real example of a PCA in a genetics paper: https://t.co/I1hHHeJuZ4 Why didn't they remove the individuals that are distributed along the PCA clines? Because that's not the point. In fact, the point is usually to capture as much var
@PollaMikko @tuukka_kuru https://t.co/uqN8I4Uc1t ”Europeans can be divided into two groups based on an analysis of protein-coding genetic variations – into Finns and non-Finns, reports Nature.” Suomensukuiset ovat selvästi muista eroava väestö, meillä on
@EPolemicist @DBlossius @rasmansa That PCA is from this paper btw: https://t.co/I1hHHeJuZ4 Also it's worth pointing out that the paper that "meme-ified" PCA is lifted from does not support race essentialism at all. Feldman and Cavalli-Sforza are authors,
Since the very first release of large scale exome database by @gnomad_project there has been extraordinary interest in quantifying the mutational constraints of protein coding genes. https://t.co/OzmTcezul7
@VaporubQueen @Chongxi_Bai Diferencias raciales en el coeficiente intelectual https://t.co/m5Kg1o0kX3 Comportamiento criminal hereditario https://t.co/QMUkZTf2NJ Los africanos tienen un número significativamente mayor de variantes de truncamiento de pr
@Caroline_Bartma @maxfalkowitz https://t.co/rZAm4sCVO5 average person has ~35 homozygous protein truncation variants!
@LimitedRunDoug I mean, it's possible that someone in your ancestry did settle from Norway, but the Finnish DNA is apparently rather unique that there's clearly a lot less Norway in there. Some people group Europeans into "Finns" and "non-Finns". https://
@rvalimaki @LaaksoSheikki Tämä on olkiukko. Tottakai suomalaiset ovat geneettisesti sekakansaa, koska joka ikinen ihminen on geneettinen sekoitus. Itäsuomalaiset eroavat varmuudella esim. thaimaalaisesta enemmän kuin muista suomalaisista. Ruotsalaiset ei
@BetaCommando @MarinaLampinen Tämä lienee alkuperäinen lähde.. https://t.co/9BN5KWBIGU
@pleunipennings Not exactly an answer to your Q but the EXAC paper says “CpG transitions, the most likely mutational event, begin reaching saturation at ~20,000 individuals” in *exome*! They don’t talk about other mutations I guess. https://t.co/96XtTXnkbw
RT @HuuhtanenPanu: Suomalaiset ovat uniikki #alkuperäiskansa, jota on SUOJELTAVA #vieraslajit:eilta. #Nature-lehdessä julkaistu tutkimus @…
Suomalaiset ovat uniikki #alkuperäiskansa, jota on SUOJELTAVA #vieraslajit:eilta. #Nature-lehdessä julkaistu tutkimus @nresearchnews: https://t.co/KOPGNoICaR Suomeksi aiheesta: https://t.co/X5yjRNker2
@rvalimaki @SeidaSohrabi @AppelsinUlla Idän ja lännen välillä on tosiaan eroja. Itää on syrjitty hyvin monella tapaa vuosisatoja. Kuopiolaisia ei Helsingissä enää ylenkatsota mongoleina, vaan savolaisina. Ennakkoluuloja on yhä merkillisen paljon, kun ottaa
@theFourier2k @YaleGenetics ML: part of ExAC (citing https://t.co/OdFRxdrrzX). Goals to interpret rare variants in disease genes, looking at genetics in non-EU, and identifying genes that are functionally constrained
@GrandeHefe @SeidaSohrabi "Suomalaiset ovat perimältään niin erilaisia muista eurooppalaisista, että heidät pitää luokitella omaksi väestökseen, summataan Itä-Suomen yliopiston tutkimustiedotteessa." https://t.co/PaTSziBwIY
@MikaelJungner @SeidaSohrabi Tutkijat ovat sinun kanssasi täysin erimieltä faktisesti. Ei mielipiteenä vaan tutkimuksen kautta. ”Suomalaiset” ja ”ei-suomalaiset”. Näihin kahteen ryhmään jaetaan eurooppalaiset tuoreessa Nature-tiedejulkaisussa.. https://t.
@markkujantero @laine_alma @SeidaSohrabi Se on tieteellistä faktaa. Se ei ole uskomus eikä uskon asia. On sinun asiasi uskotko tieteellistä faktaa vai omaa perstuntumaa, mutta on faktinen tosiasia, että perstuntumasi on väärä. https://t.co/8jnMWS9WU7
@mihkal @AnneTorppa Itseasiassa meidän eroavuudet kaikista muista kansoista on suorastaan poikkeuksellisen eroava. Me olemme täysin oma lajimme. "Suomalaiset ovat perimältään niin erilaisia muista eurooppalaisista, että heidät pitää luokitella omaksi väe
Analysis of protein-coding genetic variation in 60,706 humans https://t.co/5XUpEoaEqS
@AenesidemusOZ @Ausshot3Dave @WDP_HeathGeorge Then read the original paper. Billion genes but not even one beneficial mutation. https://t.co/2OxnuhA2od
@BobbyJEyeGuy @IHEC_Epigenomes Would suggest the ExAC paper: https://t.co/C4Dux8cQ0a. Apart from the solid and broadly useful genetics in it, it is a great example of open data sharing (1/2).
@Rosewind2007 @glenpyle @WiringTheBrain The Finns are quite distinct genetically from other European populations - https://t.co/fjbmNKX1cQ
@JukkaWallin @KarnaMikko Jos sinulla on joku pointti, niin ehkä kerrot sen tarkemmin. Tässä Naturessa julkaistu tutkimus, jota US referoi: https://t.co/mMNCNF2Kuh
@TonySpencer4 The problem is that we don't know which problems 'affect all groups' until we have a properly diverse dataset. eg out of 192 gene variations shown to be linked to disease in Western populations, just 9 of these disease in South Asians. https:
RT @shi_huang5: Figure 5B in Lek et al show that Africans have significantly more protein truncating variants than other groups. This impor…
RT @TheRichardDoyle: .@ZahiHawass — Kindly inform Khaled El-Anany that the Australia–Egypt Treaty (1930s) shall soon no longer be recognise…
RT @shi_huang5: The intuition of Jim Watson on African IQ has no scientific basis? or is it political incorrectness? Why is everyone quiet…
RT @shi_huang5: Figure 5B in Lek et al show that Africans have significantly more protein truncating variants than other groups. This impor…
RT @TheRichardDoyle: .@ZahiHawass — Kindly inform Khaled El-Anany that the Australia–Egypt Treaty (1930s) shall soon no longer be recognise…
RT @shi_huang5: The intuition of Jim Watson on African IQ has no scientific basis? or is it political incorrectness? Why is everyone quiet…
RT @shi_huang5: Figure 5B in Lek et al show that Africans have significantly more protein truncating variants than other groups. This impor…
RT @TheRichardDoyle: .@ZahiHawass — Kindly inform Khaled El-Anany that the Australia–Egypt Treaty (1930s) shall soon no longer be recognise…
RT @shi_huang5: Figure 5B in Lek et al show that Africans have significantly more protein truncating variants than other groups. This impor…
RT @shi_huang5: The intuition of Jim Watson on African IQ has no scientific basis? or is it political incorrectness? Why is everyone quiet…
RT @TheRichardDoyle: .@ZahiHawass — Kindly inform Khaled El-Anany that the Australia–Egypt Treaty (1930s) shall soon no longer be recognise…
.@ZahiHawass — Kindly inform Khaled El-Anany that the Australia–Egypt Treaty (1930s) shall soon no longer be recognised — and the Repatriation of, essentially Egypt, to a new Australia is imminent. Cc: .@b0yle .@Sierralobo .@StateDept .@CliveFPalmer ht
RT @shi_huang5: Figure 5B in Lek et al show that Africans have significantly more protein truncating variants than other groups. This impor…
RT @shi_huang5: The intuition of Jim Watson on African IQ has no scientific basis? or is it political incorrectness? Why is everyone quiet…
The intuition of Jim Watson on African IQ has no scientific basis? or is it political incorrectness? Why is everyone quiet on the remarkable finding that Africans have more protein truncating variants or deleterious mutations than other human groups?@charl
RT @michaelhoffman: KJ: Human site frequency spectrum not accurately explained by infinite sites model (= no recurrent mutation). #probgen1…
KJ: Human site frequency spectrum not accurately explained by infinite sites model (= no recurrent mutation). #probgen18 https://t.co/D1z2qtDD1O
@jhaakana @HarrinTwiitit Siten, että yritin laittaa linkin, mutta toisessa keskusteluketjussa kävin keskustelua tästä somessa, linkit menivät sekaisin, enkä heti huomannut. My bad.. https://t.co/NquVtxE1rL
@jakepmann @dgmacarthur And a very nice paper summarising the different applications and interpretations in genomics - https://t.co/SYoKwqf4Be
RT @DaleYuzuki: Lek: #NGDx18 ExAC paper '16 Nature https://t.co/0th4EHbN1I For affected individual, narrow down from 11K to 132 suspected m…
Lek: #NGDx18 ExAC paper '16 Nature https://t.co/0th4EHbN1I For affected individual, narrow down from 11K to 132 suspected mutations to follow-up on
Today in #GCD8920, we're discussing the ExAC paper: Analysis of protein-coding genetic variation in 60,706 humans https://t.co/PHWkQ8z9vI
RT @leilaluheshi: Read this + imagine what could be achieved for rare disease patients if clinical genetics labs ALL shared their data http…
RT @leilaluheshi: Read this + imagine what could be achieved for rare disease patients if clinical genetics labs ALL shared their data http…
Figure 5B in Lek et al show that Africans have significantly more protein truncating variants than other groups. This important new result would rewrite human origin models and is being overlooked by the establishment for nonscientific reasons! https://t.c
KS: Mutational model accurately predicts synonymous variation (https://t.co/VSqGUJnJ7A, https://t.co/EwK6qoFjsu) #HGH17
RT @AFPopgen: JW: Strong enrichment of LoF-intolerant genes in SCZ (https://t.co/bsq42aGWsV) independent of brain expression #WCPG2017
RT @AFPopgen: JW: Strong enrichment of LoF-intolerant genes in SCZ (https://t.co/bsq42aGWsV) independent of brain expression #WCPG2017
JW: Strong enrichment of LoF-intolerant genes in SCZ (https://t.co/bsq42aGWsV) independent of brain expression #WCPG2017
@McDawg The ExAC Nature publication is CC BY 4.0. See https://t.co/SCFZnnLGI3
Today’s GCB534 reading: ExAC from @dgmacarthur and colleagues. https://t.co/clA1GXcadd
RT @yuji_ikegaya: 今朝の『ネイチャー』誌で60,706人の遺伝子の大規模解析データがついに発表! 新たな病因候補も多数見つかりました。スゴい!→https://t.co/UI3oVp8BoL(想像していたよりヒトの遺伝子は個性豊かでした。実際、人口の13%は何…
"suomalaisiin ja ei-suomalaisiin"! 😉 https://t.co/mPzTbMnCkv
So, it's now proven, Finns are unique! "We further separated Europeans into individuals of Finnish and... https://t.co/83fQDtT7uU
RT @dgmacarthur: @hoffsbeefs @ClementYChow @MollyGasp Most genes have eQTLs in GTEx (https://t.co/MxC5gKidT5), but genes w/ LoF constraint…
RT @dgmacarthur: @hoffsbeefs @ClementYChow @MollyGasp Most genes have eQTLs in GTEx (https://t.co/MxC5gKidT5), but genes w/ LoF constraint…
RT @dgmacarthur: @hoffsbeefs @ClementYChow @MollyGasp Most genes have eQTLs in GTEx (https://t.co/MxC5gKidT5), but genes w/ LoF constraint…
RT @dgmacarthur: @hoffsbeefs @ClementYChow @MollyGasp Most genes have eQTLs in GTEx (https://t.co/MxC5gKidT5), but genes w/ LoF constraint…
@hoffsbeefs @ClementYChow @MollyGasp Most genes have eQTLs in GTEx (https://t.co/MxC5gKidT5), but genes w/ LoF constraint are depleted in eQTLs (https://t.co/VWSQNuO7qb Fig 3d)
la tasa de generación de raw data genómica supera a la astronómica https://t.co/mJsb4lHtPN
@pjobphd More like genes intolerant of somatic changes. @chrisamiller pointed out similar germline genes in the ExAC paper https://t.co/eJTLxZ7QCJ
@roelverhaak The ExAC paper has some of that - identifying "essential" genes with a paucity of LoF mutations: https://t.co/H1gnh0gOO1
Congrats to our colleague @dgmacarthur; winner of Martin Prize for outstanding clinical research paper https://t.co/VtzylXfMAB
RT @yuji_ikegaya: 今朝の『ネイチャー』誌で60,706人の遺伝子の大規模解析データがついに発表! 新たな病因候補も多数見つかりました。スゴい!→https://t.co/UI3oVp8BoL(想像していたよりヒトの遺伝子は個性豊かでした。実際、人口の13%は何…
This is a tremendous data set: Analysis of protein-coding genetic variation in 60,706 humans https://t.co/UoXHOUkkBY
Analysis of protein-coding genetic variation in 60,706 humans published as: https://t.co/EBfEiOHvmT @nature #biorxiv
RT @yuji_ikegaya: 今朝の『ネイチャー』誌で60,706人の遺伝子の大規模解析データがついに発表! 新たな病因候補も多数見つかりました。スゴい!→https://t.co/UI3oVp8BoL(想像していたよりヒトの遺伝子は個性豊かでした。実際、人口の13%は何…
Analysis of protein-coding genetic variation in 60,706 humans https://t.co/xFK6m69hXx
Analysis of protein-coding genetic variation in 60,706 humans https://t.co/sTIU8b7xMo
Top story #ASHG16: Analysis of protein-coding genetic variation in 60,706 human… https://t.co/gycZWsLLFh, see more https://t.co/QOb0T4lSIk
RT @NatureGenet: Analysis of protein-coding #genetic variation in 60,706 humans https://t.co/aNAPQ5tHsR via @nature #ASHG16 #ExAC https://t…
RT @yuji_ikegaya: 今朝の『ネイチャー』誌で60,706人の遺伝子の大規模解析データがついに発表! 新たな病因候補も多数見つかりました。スゴい!→https://t.co/UI3oVp8BoL(想像していたよりヒトの遺伝子は個性豊かでした。実際、人口の13%は何…
@NatureNews but @nature does make some exceptions? @dgmacarthur how did https://t.co/MspGr833Q8 end up as CC BY?
@Awesomics 72% of 3230 genes w/o any protein-truncating variants in ExAC have no established human disease phenotype https://t.co/g3dV4XcbH4
https://t.co/cuZhj9QxJX 遺伝子の多様性はセーフティネット。社会保障により保たれている。誰かが見捨てずに助けてくれるから生きてゆける。今日の秩序がある。いかに最大多数の幸福を実現するか?理解者と仲介者。パイを大きくするためにすべきことく(ぅ(¬)l向*、ゝ
RT @juhasaarinen: "the term European hereafter refers to non-Finnish European individuals." Oh dear. https://t.co/Py3z8D5vR4
"the term European hereafter refers to non-Finnish European individuals." Oh dear. https://t.co/Py3z8D5vR4
OF NOTE: Analysis of protein-coding genetic variation in 60,706 humans. https://t.co/pewrYTreXq
RT @yuji_ikegaya: 今朝の『ネイチャー』誌で60,706人の遺伝子の大規模解析データがついに発表! 新たな病因候補も多数見つかりました。スゴい!→https://t.co/UI3oVp8BoL(想像していたよりヒトの遺伝子は個性豊かでした。実際、人口の13%は何…
Analysis of protein-coding genetic variation in 60,706 humans : Nature : Nature Research https://t.co/DCGfz4k6YZ
60,000 people had there gene sequenced to show 3,000 genes had no mutation Yet 72% of those genes are unkown #bio346 https://t.co/0uQ0IGcSBh
https://t.co/WpzD3g4ls6 A MASSIVE sequencing project (of +60,000 people) has shown that ~3,000 genes have virtually no mutations and yet 7…
#Science https://t.co/x8D10uOK3Q A MASSIVE sequencing project (of +60,000 people) has shown that ~3,000 genes have virtually no mutations …
https://t.co/8ZfDhtwCzj A MASSIVE sequencing project (of +60,000 people) has shown that ~3,000 genes have virtually no mutations and yet 7…
Never forget the environment. Analysis of protein-coding genetic variation in 60,706 humans https://t.co/b2cXbsizwu
RT @NatureGenet: Analysis of protein-coding #genetic variation in 60,706 humans https://t.co/aNAPQ5tHsR via @nature #ASHG16 #ExAC https://t…
#Genetic #mutations wrongly #misclassified as #harmful / #NATURE https://t.co/ULvBcYpHJ8
RT @NatureGenet: Analysis of protein-coding #genetic variation in 60,706 humans https://t.co/aNAPQ5tHsR via @nature #ASHG16 #ExAC https://t…