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RT @TalhaBadarMD: Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia https://t.co/kJ…
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RT @TalhaBadarMD: Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia https://t.co/kJ…
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Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia https://t.co/kJc2oCWmGR RUNX1/CEBPA or RAS-RTK pathway genes is the main driver of acquired resistance; BCOR, homologous IDH gene, and TET2. https://t
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So cool Koichi! Looking forward to reading!
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RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
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"These data suggest that targeting stemness and certain high-risk co-occurring mutations may overcome resistance to IDHi in AML."
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RT @NatureComms: #Multiomics analysis by @DrKTakahashi @MDAndersonNews reveals that #resistance to IDH #inhibitors in acute myeloid #leukae…
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RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
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RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
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RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
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RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
1,321 followers
RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
1,841 followers
RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
1,312 followers
RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
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RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
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RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
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RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
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RT @DrKTakahashi: Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in…
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Excited to share our recent publication in @NatureComms describing the molecular correlates of IDH inhibitor response in AML. We found that stemness signature is predictive of primary resistance to IDH inhibitors while selection of resistant mutations driv
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RT @cancerscnews: Scientists in this 🆕 @NatureComms paper reveal that #leukemia stemness is a major driver of primary resistance to isocitr…
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Scientists in this 🆕 @NatureComms paper reveal that #leukemia stemness is a major driver of primary resistance to isocitrate dehydrogenase inhibitors. #OpenAccess | https://t.co/z0kJ3m6WnA https://t.co/IZXdIM4CnI
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RT @NatureComms: #Multiomics analysis by @DrKTakahashi @MDAndersonNews reveals that #resistance to IDH #inhibitors in acute myeloid #leukae…
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'In this work, we perform an integrated genomic analysis combining DNA sequencing, RNA sequencing, and methylation profiling microarray on bone marrow samples collected longitudinally from AML patients treated with IDHi' https://t.co/LkkmGpHrHQ
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RT @NatureComms: #Multiomics analysis by @DrKTakahashi @MDAndersonNews reveals that #resistance to IDH #inhibitors in acute myeloid #leukae…
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RT @NatureComms: #Multiomics analysis by @DrKTakahashi @MDAndersonNews reveals that #resistance to IDH #inhibitors in acute myeloid #leukae…
1,312 followers
RT @NatureComms: #Multiomics analysis by @DrKTakahashi @MDAndersonNews reveals that #resistance to IDH #inhibitors in acute myeloid #leukae…
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RT @NatureComms: #Multiomics analysis by @DrKTakahashi @MDAndersonNews reveals that #resistance to IDH #inhibitors in acute myeloid #leukae…
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RT @NatureComms: #Multiomics analysis by @DrKTakahashi @MDAndersonNews reveals that #resistance to IDH #inhibitors in acute myeloid #leukae…
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RT @NatureComms: #Multiomics analysis by @DrKTakahashi @MDAndersonNews reveals that #resistance to IDH #inhibitors in acute myeloid #leukae…
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#Multiomics analysis by @DrKTakahashi @MDAndersonNews reveals that #resistance to IDH #inhibitors in acute myeloid #leukaemia #AML is driven by #stemness and high-risk #mutations 🧬💊 #CancerResearch @NatResCancer https://t.co/VrTKXyNBu2
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解析を行なったプロジェクトがNature Communicationsにパブリッシュされました（共著)。 急性骨髄性白血病において、共起する遺伝子変異で白血病幹細胞化が起き、IDH阻害剤への耐性をもたらすことを明らかにしました。 https://t.co/KOR54VpnGg