A lysinecysteine redox switch with an NOS bridge regulates enzyme function https://t.co/G6A35sT01N #science
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
A lysinecysteine redox switch with an NOS bridge regulates enzyme function https://t.co/nQTahy0dhD #science
RT @souyakuchan: Lys-Cys間架橋の発見、Nature。 淋菌のトランスアルドラーゼで見つかった。酸化還元スイッチとして、Lys-Cys結合がアロステリックに酵素活性を制御。ほか既知のPDB構造内にもありそうとのこと。 A lysine–cysteine r…
RT @manuelacasasoli: Previously unnoticed N–O–S bridges. A new regulatory protein crosslink: an oxygen atom connects a nitrogen to a sulfu…
RT @uniGoettingen: Just to show that there are always unexpected discoveries, researchers at our Uni found a new chemical switch that can c…
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
A Pandora's box N-O-S https://t.co/uCPQOBforl
RT @DrEMBahnson: A lysine–cysteine redox switch with an NOS bridge regulates enzyme function https://t.co/CE1Cw0aRIp When you think you are…
RT @ADHansonLab: Another in the series 'Who knew cysteine could do this?' ⬇️An N-O-S bridge btwn Cys & Lys side chains in transaldolase (&…
A lysine–cysteine redox switch with an NOS bridge regulates enzyme function https://t.co/CE1Cw0aRIp When you think you are starting to know, then you know that you don't know. Discovery is exciting and even when you think all's been said about protein redo
RT @manuelacasasoli: Previously unnoticed N–O–S bridges. A new regulatory protein crosslink: an oxygen atom connects a nitrogen to a sulfu…
RT @uniGoettingen: Just to show that there are always unexpected discoveries, researchers at our Uni found a new chemical switch that can c…
RT @uniGoettingen: Just to show that there are always unexpected discoveries, researchers at our Uni found a new chemical switch that can c…
Just to show that there are always unexpected discoveries, researchers at our Uni found a new chemical switch that can control the structure and function of proteins. It seems to be everywhere but was overlooked until now: https://t.co/41Wxvion4G, https://
RT @notherChemist: Guess what! We found a new type of bond in peptides. Read about it in: A lysine–cysteine redox switch with an NOS bridge…
ハァ・・・ハァ・・・こないだのnatureの論文( https://t.co/lAxhNdXgW3 )を読み終わったぞ・・・・・・_:(´ཀ`」 ∠):_
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @manuelacasasoli: Previously unnoticed N–O–S bridges. A new regulatory protein crosslink: an oxygen atom connects a nitrogen to a sulfu…
RT @manuelacasasoli: Previously unnoticed N–O–S bridges. A new regulatory protein crosslink: an oxygen atom connects a nitrogen to a sulfu…
RT @manuelacasasoli: Previously unnoticed N–O–S bridges. A new regulatory protein crosslink: an oxygen atom connects a nitrogen to a sulfu…
@mtbolic @IsmaelMingarro
Previously unnoticed N–O–S bridges. A new regulatory protein crosslink: an oxygen atom connects a nitrogen to a sulfur atom. #Science #protein #structuralbiology #Biology ⏯️Previously unknown type of protein crosslink discovered https://t.co/eFGpiMbO5D
😲😲
This is cool! Curious to see where else this occurs.
RT @sdelagrave: Very cool discovery about protein chemistry: a new type of bond found between lys and cys side-chains in many proteins acro…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
A new type of protein crosslink! I had a simple life being only aware of -S-S- bridges, and now this: A lysine–cysteine redox switch with an NOS bridge regulates enzyme function | Nature https://t.co/qmP5HntxW9
Conditions for formation of NOS bridge not well defined (incubation at 6 C for a couple of weeks?) They talk about removal of excess DTT using desalting column, which means some DTT left. DTT would react with dioxygen and a nonphysiologically relevant NOS
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
Very cool discovery about protein chemistry: a new type of bond found between lys and cys side-chains in many proteins across all domains of life... https://t.co/7TB4Cf5hdH
RT @A_AlShamkhani: Paradigm shift. https://t.co/CWZY8jzXwR
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
Una PISTA en la "marabunta" de datos... Esta investigación descubre un vínculo proteico entre los residuos de cisteína y lisina en una enzima transaldolasa. Este puente NOS sirve para regular la actividad enzimática y bien puede estar escondido a simple v
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
Paradigm shift.
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @ADHansonLab: Another in the series 'Who knew cysteine could do this?' ⬇️An N-O-S bridge btwn Cys & Lys side chains in transaldolase (&…
水分子のOが見えているわけではなく? 大本の電子密度を自分でいじって、原子間距離とか見てみたいけれど、こういうのを見るとこれから生物やるのに化学は必須だなぁと思う
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
RT @nature: Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge…
Research in Nature discovers a protein linkage between cysteine and lysine residues in a transaldolase enzyme. This NOS bridge serves to regulate enzyme activity and may well be hiding in plain sight in other proteins. https://t.co/apCyRIuuyA https://t.co/
RT @KevinKaichuang: It's 2021 and we just discovered a new covalent crosslink in protein structures! And the covalent Cys-Lys crosslink vi…
RT @KevinKaichuang: It's 2021 and we just discovered a new covalent crosslink in protein structures! And the covalent Cys-Lys crosslink vi…
RT @ADHansonLab: Another in the series 'Who knew cysteine could do this?' ⬇️An N-O-S bridge btwn Cys & Lys side chains in transaldolase (&…
RT @ADHansonLab: Another in the series 'Who knew cysteine could do this?' ⬇️An N-O-S bridge btwn Cys & Lys side chains in transaldolase (&…
RT @ADHansonLab: Another in the series 'Who knew cysteine could do this?' ⬇️An N-O-S bridge btwn Cys & Lys side chains in transaldolase (&…
RT @ADHansonLab: Another in the series 'Who knew cysteine could do this?' ⬇️An N-O-S bridge btwn Cys & Lys side chains in transaldolase (&…
RT @ADHansonLab: Another in the series 'Who knew cysteine could do this?' ⬇️An N-O-S bridge btwn Cys & Lys side chains in transaldolase (&…
RT @KevinKaichuang: It's 2021 and we just discovered a new covalent crosslink in protein structures! And the covalent Cys-Lys crosslink vi…
Another in the series 'Who knew cysteine could do this?' ⬇️An N-O-S bridge btwn Cys & Lys side chains in transaldolase (& other enzymes). Mechanism of formation unknown, apparently unprecedented, likely involves attack by an oxidized Cys-S on Lys-N
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
Wild chemistry and very cool structural biology!
RT @souyakuchan: Lys-Cys間架橋の発見、Nature。 淋菌のトランスアルドラーゼで見つかった。酸化還元スイッチとして、Lys-Cys結合がアロステリックに酵素活性を制御。ほか既知のPDB構造内にもありそうとのこと。 A lysine–cysteine r…
RT @notherChemist: Guess what! We found a new type of bond in peptides. Read about it in: A lysine–cysteine redox switch with an NOS bridge…
RT @notherChemist: Guess what! We found a new type of bond in peptides. Read about it in: A lysine–cysteine redox switch with an NOS bridge…
A super cool paper!
RT @KevinKaichuang: It's 2021 and we just discovered a new covalent crosslink in protein structures! And the covalent Cys-Lys crosslink vi…
RT @JohanaMisas: This is really amazing! 🤯👇 A lysine–cysteine redox switch with an NOS bridge regulates enzyme function…
RT @LesliePoolePhD: This is ... a big surprise!
When a Cys meets a Lys? A magic chemistry will be performed by the Nature!
RT @notherChemist: Guess what! We found a new type of bond in peptides. Read about it in: A lysine–cysteine redox switch with an NOS bridge…
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
RT @souyakuchan: Lys-Cys間架橋の発見、Nature。 淋菌のトランスアルドラーゼで見つかった。酸化還元スイッチとして、Lys-Cys結合がアロステリックに酵素活性を制御。ほか既知のPDB構造内にもありそうとのこと。 A lysine–cysteine r…
RT @souyakuchan: Lys-Cys間架橋の発見、Nature。 淋菌のトランスアルドラーゼで見つかった。酸化還元スイッチとして、Lys-Cys結合がアロステリックに酵素活性を制御。ほか既知のPDB構造内にもありそうとのこと。 A lysine–cysteine r…
RT @souyakuchan: Lys-Cys間架橋の発見、Nature。 淋菌のトランスアルドラーゼで見つかった。酸化還元スイッチとして、Lys-Cys結合がアロステリックに酵素活性を制御。ほか既知のPDB構造内にもありそうとのこと。 A lysine–cysteine r…
RT @souyakuchan: Lys-Cys間架橋の発見、Nature。 淋菌のトランスアルドラーゼで見つかった。酸化還元スイッチとして、Lys-Cys結合がアロステリックに酵素活性を制御。ほか既知のPDB構造内にもありそうとのこと。 A lysine–cysteine r…
RT @souyakuchan: Lys-Cys間架橋の発見、Nature。 淋菌のトランスアルドラーゼで見つかった。酸化還元スイッチとして、Lys-Cys結合がアロステリックに酵素活性を制御。ほか既知のPDB構造内にもありそうとのこと。 A lysine–cysteine r…
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
This is ... a big surprise!
RT @KevinKaichuang: It's 2021 and we just discovered a new covalent crosslink in protein structures! And the covalent Cys-Lys crosslink vi…
RT @CommichauM: A fantastic paper by Marie Weisen et al., a team member of our iGEM team 2018! 👉A lysine–cysteine redox switch with an NOS…
RT @Bio_stations: アミノ酸のクロスリンクといえばS-S結合が有名だが、今回構造解析をベースに新たな結合としてS-O-N結合を報告(!) リシンとシステインの結合になるらしい。酵素活性を制御する役割があるかも。多くのタンパク質で存在する可能性も示唆 いやいや…
RT @notherChemist: Guess what! We found a new type of bond in peptides. Read about it in: A lysine–cysteine redox switch with an NOS bridge…
RT @JohanaMisas: This is really amazing! 🤯👇 A lysine–cysteine redox switch with an NOS bridge regulates enzyme function…
RT @notherChemist: Guess what! We found a new type of bond in peptides. Read about it in: A lysine–cysteine redox switch with an NOS bridge…
RT @uniGoettingen: Überraschte Gesichter im Lab: Forscher*innen unserer Uni haben einen völlig neuartigen, aber bisher übersehenen „An/Aus-…
RT @BrettGarabedian: N-O-S bond 🤯 https://t.co/0cfiz5TEX7